Circadian rhythm in hepatic low-density-lipoprotein (LDL)-receptor expression and plasma LDL levels
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چکیده
منابع مشابه
A Novel Mutation in Exon 4 of the Low Density Lipoprotein (LDL) Receptor Gene in an Iranian Familial Hypercholesterolemia Patient
Familial hypercholesterolemia (FH) is an autosomal co-dominant disorder of lipid metabolism, caused by mutations in LDL receptor gene. The penetrance of FH is almost 100%, meaning that half of the offspring of affected parents born with disease. The patients are at risk of premature coronary heart disease (CHD). There is no report about the molecular basis of FH in Iran. Identification of mutat...
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Oxidized low density lipoprotein (ox-LDL) and its scavenger receptor LOX-1 expression in osteoarthritis Aspasia Tsezou1,2,3, Theodora Simopoulou1, Lazaros Poultsides4, Sokratis Varitimidis4, Konstantinos N. Malizos3,4 1Department of Cytogenetics and Molecular Genetics, University of Thessalia, Larissa, Greece; 2Department of Biology, University of Thessalia, Larissa, Greece; 3Institute for Biom...
متن کاملDiscordance of low-density lipoprotein (LDL) cholesterol with alternative LDL-related measures and future coronary events.
BACKGROUND Low-density lipoprotein cholesterol (LDL-C) is the traditional measure of risk attributable to LDL. Non-high-density lipoprotein cholesterol (NHDL-C), apolipoprotein B (apoB), and LDL particle number (LDL-P) are alternative measures of LDL-related risk. However, the clinical utility of these measures may only become apparent among individuals for whom levels are inconsistent (discord...
متن کاملReactivity of direct assays for low-density lipoprotein (LDL) cholesterol toward charge-modified LDL in hypercholesterolemia.
BACKGROUND The aim of the present study was to compare 2 direct measurements for low-density lipoprotein cholesterol (LDL-C) with the Friedewald calculation (LDL-C [F]) in serum and their relationship with size-and charge-based LDL subfractions in serum ultracentrifugation fractions in patients with hypercholesterolemia (HC). METHODS AND RESULTS Serum samples from 283 HC patients who particip...
متن کاملMathematical Model for Low Density Lipoprotein (LDL) Endocytosis by Hepatocytes
Individuals with elevated levels of plasma low density lipoprotein (LDL) cholesterol (LDL-C) are considered to be at risk of developing coronary heart disease. LDL particles are removed from the blood by a process known as receptor-mediated endocytosis, which occurs mainly in the liver. A series of classical experiments delineated the major steps in the endocytotic process; apolipoprotein B-100...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1994
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2980039